Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis eBook


Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis
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Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis


Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis
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Author : Charles C. Capen
language : en
Publisher: Oxford University Press, USA
Release Date : 1999

Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis written by Charles C. Capen and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Bladder categories.


An IARC workshop held in Lyon, Nov. 3-7, 1997.



Genetic Toxicology And Cancer Risk Assessment


Genetic Toxicology And Cancer Risk Assessment
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Author : Wai Nang Choy
language : en
Publisher: CRC Press
Release Date : 2001-08-31

Genetic Toxicology And Cancer Risk Assessment written by Wai Nang Choy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-08-31 with Medical categories.


Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.



Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances


Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances
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Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
language : en
Publisher: IARC Monographs on the Evaluat
Release Date : 1999

Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and has been published by IARC Monographs on the Evaluat this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.


Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine



Some Thyrotropic Agents


Some Thyrotropic Agents
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Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
language : en
Publisher: World Health Organization
Release Date : 2001

Some Thyrotropic Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Health & Fitness categories.


This publication represents the views and expert opinions of an IARC Working Group which met in Lyon, 10-17 October 2000.



Boorman S Pathology Of The Rat


Boorman S Pathology Of The Rat
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Author : Andrew W. Suttie
language : en
Publisher: Academic Press
Release Date : 2017-12-18

Boorman S Pathology Of The Rat written by Andrew W. Suttie and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-18 with Medical categories.


Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research



Invasive Bladder Cancer


Invasive Bladder Cancer
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Author : PierFrancesco Bassi
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-29

Invasive Bladder Cancer written by PierFrancesco Bassi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-29 with Medical categories.


Invasive bladder tumors affect the muscle wall, and have a propensity to metastasize and spread to other areas of the body, and are more likely to be fatal. This book presents state-of-the-art diagnoses and treatments available for bladder cancer that has metastasised into the body. A thorough review of current practice is presented in a full color volume with more than 40 tables and 50 illustrations. The book offers a comprehensive review of the subject, covering epidemiology, screening, diagnostic factors, surgery, chemotherapy and post-operative monitoring. Most chapters are jointly written by a basic researcher and a clinician.



Toxicologic Pathology


Toxicologic Pathology
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Author : Pritam S. Sahota
language : en
Publisher: CRC Press
Release Date : 2018-08-14

Toxicologic Pathology written by Pritam S. Sahota and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-14 with Medical categories.


Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.