Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances eBook
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Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances
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Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
language : en
Publisher: IARC Monographs on the Evaluat
Release Date : 1999
Some Chemicals That Cause Tumours Of The Kidney Or Urinary Bladder In Rodents And Some Other Substances written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and has been published by IARC Monographs on the Evaluat this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine
Some Chemicals That Cause Tumours Of The Urinary Tract In Rodents
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Author : International Agency for Research on Cancer
language : en
Publisher: International Agency for Research on Cancer
Release Date : 2019-10-24
Some Chemicals That Cause Tumours Of The Urinary Tract In Rodents written by International Agency for Research on Cancer and has been published by International Agency for Research on Cancer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Law categories.
This volume of the IARC Monographs provides evaluations of the carcinogenicity of: melamine, a chemical that is used to make plastic materials, including coatings, filters, adhesives, and kitchenware, and that has also been used illegally to adulterate foods and animal feeds; 1-tert-butoxypropan-2-ol, a solvent that is used as a substitute for other glycol ethers and in various consumer products; myrcene, which is found in a wide variety of plants and is used mainly as a raw material in the manufacture of chemicals such as menthol but also as a fragrance and flavoring substance; furfuryl alcohol, a chemical that is used as a solvent and in the production of furan resins and wetting agents, and that can also be formed in coffee and food during roasting, baking, or deep-frying; pyridine, a chemical that is used as a solvent or intermediate in the manufacture of pesticides, flavoring agents, vitamins, drugs, and dyes, and is also found in cigarette smoke; tetrahydrofuran, a chemical that is used as a solvent in plastics, dyes, elastomers, and glues, and is also used in the synthesis of motor fuels and in the manufacture of pharmaceuticals; and vinylidene chloride, a chemical that is used mainly in the production of copolymers for the manufacture of films for food packaging. Exposure to all seven agents considered may occur in different occupational settings as well as in the general population. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.
Carcinogens And Anticarcinogens In The Human Diet
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1996-02-12
Carcinogens And Anticarcinogens In The Human Diet written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-12 with Nature categories.
Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
How Tobacco Smoke Causes Disease
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Author :
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Tumour Site Concordance And Mechanisms Of Carcinogenesis
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Author : Robert A. Baan
language : en
Publisher: International Agency for Research on Cancer
Release Date : 2019-05-22
Tumour Site Concordance And Mechanisms Of Carcinogenesis written by Robert A. Baan and has been published by International Agency for Research on Cancer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-22 with Medical categories.
This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.
Chemical Carcinogenesis
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Author : Trevor M. Penning
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-03
Chemical Carcinogenesis written by Trevor M. Penning and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-03 with Medical categories.
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Mutagenic Impurities
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Author : Andrew Teasdale
language : en
Publisher: John Wiley & Sons
Release Date : 2022-02-15
Mutagenic Impurities written by Andrew Teasdale and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-15 with Medical categories.
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.