Preclinical Testing Of The Anti Diabetic Effects Of Secoisolariciresinol Diglucoside Sdg From Flaxseed In The Male Zucker Diabetic Fatty Rat eBook
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Preclinical Testing Of The Anti Diabetic Effects Of Secoisolariciresinol Diglucoside Sdg From Flaxseed In The Male Zucker Diabetic Fatty Rat
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Author : Rachel F. Noirot
language : en
Publisher:
Release Date : 2006
Preclinical Testing Of The Anti Diabetic Effects Of Secoisolariciresinol Diglucoside Sdg From Flaxseed In The Male Zucker Diabetic Fatty Rat written by Rachel F. Noirot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Scientific data have demonstrated a marked effect of diets containing the secoisolaricireninol diglucoside (SDG) antioxidant component from flaxseed on lipid and blood parameters in obese rats. SDG may ameliorate insulin-resistance risk factors associated Type II DM. This investigation was made to determine the effects of SDG from flaxseed in male ZDF rats, a model of human type II DM, and to investigate physiological parameters and specific genes affected by the inclusion of SDG in the diet. Comparable to a diet containing rosiglitazone, an anti-diabetic drug, an SDG diet attenuated several abnormalities observed in the animals, such as decreased cholesterol and percent lipid body composition, and noticeable down regulatory fold changes of the fatty acid synthase gene (FAS) in adipose tissue, compared to animals in the TZD and SDG/TZD groups. Results suggested a diet containing SDG/TZD was involved in improving insulin sensitivity and lipid parameters in the male ZDF rats.
Nutrition In The Prevention And Treatment Of Abdominal Obesity
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Author : Ronald Ross Watson
language : en
Publisher: Elsevier
Release Date : 2014-02-26
Nutrition In The Prevention And Treatment Of Abdominal Obesity written by Ronald Ross Watson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-26 with Medical categories.
Nutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. Nutritionists, dieticians, and healthcare providers seeking to address the abdominal obesity epidemic will use this comprehensive resource as a tool in their long-term goal of preventing chronic diseases, especially heart, vascular, and diabetic diseases. Experts from a broad range of disciplines are involved in dealing with the consequences of excessive abdominal fat: cardiology, diabetes research, studies of lipids, endocrinology and metabolism, nutrition, obesity, and exercise physiology. They have contributed chapters that define a range of dietary approaches to reducing risk and associated chronic diseases. They begin by defining visceral obesity and its major outcomes; they also discuss the importance and the challenges of dietary approaches to reduce abdominal obesity, as compared to clinical approaches, with major costs and risks. Offers detailed, well-documented reviews outlining the various dietary approaches to visceral obesity with their benefits and failures Includes chapters on types of foods, exercise, and supplements in reducing obesity and its chronic clinical companions, especially diabetes and cardiovascular disease Helps nutritionists, dieticians, and healthcare providers approach patients in making decision about nutritional therapies and clinical treatments for abdominal obesity, from an evidence-based perspective
Biotechnology Of Anti Diabetic Medicinal Plants
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Author : Saikat Gantait
language : en
Publisher: Springer Nature
Release Date : 2021-11-13
Biotechnology Of Anti Diabetic Medicinal Plants written by Saikat Gantait and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-13 with Medical categories.
This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
Atherosclerosis Hypertension And Diabetes
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Author : Grant N. Pierce
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-04-30
Atherosclerosis Hypertension And Diabetes written by Grant N. Pierce and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-30 with Medical categories.
This volume is devoted to atherosclerosis, hypertension, anddiabetes, three of the most important disease conditions in the worldtoday. Nutritional intervention, cholesterol lowering agents, lipidsthemselves, particularly oxidized LDL, protein modification byADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are alldiscussed in the context of atherosclerotic cardiovascular disease.The hypertension section focuses on factors that may be responsiblefor high blood pressure, such as genetic predisposition, vascularhyperplasia and remodeling, insulin resistance, neurological aspectssuch as hypothalamic peptides. Also discussed are the possiblecontributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drugdelivery for treatment of hypertension is also a focus.As for diabetes, the risk factors and mechanisms responsible fordiabetic vascular and cardiac dysfunction are discussed. Lipid profilechanges and fibrinolysis in diabetic patients is detailed, along withadipogenesis, diabetic cardiomyopathy, energy metabolism in thediabetic heart, vanadate as an alternative to insulin, insulinresistance mechanisms, and neurotransmitters as targets for theprevention of cardiovascular disease and diabetes.These manuscripts were invited from scientists who presented state ofthe art lectures at the XVII World Congress of the InternationalSociety for Heart Research held in Winnipeg in July 2001.
Plant And Human Health Volume 3
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Author : Munir Ozturk
language : en
Publisher: Springer
Release Date : 2019-02-21
Plant And Human Health Volume 3 written by Munir Ozturk and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-21 with Science categories.
Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, it will focus on the secondary metabolic compounds which afford protection against diseases. Lastly, Volume 3 focuses on the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.
Diet Microbe Interactions In The Gut
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Author : Kieran Tuohy
language : en
Publisher: Academic Press
Release Date : 2014-08-04
Diet Microbe Interactions In The Gut written by Kieran Tuohy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-04 with Technology & Engineering categories.
Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations
Dietary Phytochemicals
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Author : Chukwuebuka Egbuna
language : en
Publisher: Springer Nature
Release Date : 2021-08-20
Dietary Phytochemicals written by Chukwuebuka Egbuna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-20 with Science categories.
This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.