Phosphoinositide 3 Kinase In Health And Disease eBook
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Phosphoinositide 3 Kinase In Health And Disease
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Author : Christian Rommel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-17
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-17 with Medical categories.
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
Phosphoinositide 3 Kinase In Health And Disease
DOWNLOAD
READ
Author : Christian Rommel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-17
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-17 with Medical categories.
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
Phosphoinositide 3 Kinase In Health And Disease
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Author : Christian Rommel
language : en
Publisher: Springer
Release Date : 2010-10-01
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-01 with Medical categories.
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
Phosphoinositide 3 Kinase In Health And Disease
DOWNLOAD
READ
Author : Christian Rommel
language : en
Publisher: Springer
Release Date : 2010-10-01
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-01 with Medical categories.
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
Phosphoinositide 3 Kinase In Health And Disease
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READ
Author :
language : en
Publisher:
Release Date : 2010
Phosphoinositide 3 Kinase In Health And Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Protein kinases categories.
Phosphoinositides I Enzymes Of Synthesis And Degradation
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Author : Tamas Balla
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-14
Phosphoinositides I Enzymes Of Synthesis And Degradation written by Tamas Balla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Medical categories.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Pi3k And Akt Isoforms In Immunity
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Author : Margarita Dominguez-Villar
language : en
Publisher: Springer Nature
Release Date : 2022-10-15
Pi3k And Akt Isoforms In Immunity written by Margarita Dominguez-Villar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-15 with Medical categories.
This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.